The EAPC is in the process of updating the opioid cancer pain guidelines from 2012, published in Lancet Oncology. The work is undertaken by the research network, and it is anticipated that the same methodology as last time will be followed.
The GRADE system, in fact, is used to develop evidence based clinical recommendations: 16 topics were included in the previous set of recommendations on the use of opiods and will be revised, but this will be more than an update.
The content will be expanded to 11 new topics, including assessment and classification, non-opioid drugs such as NSAIDs, paracetamol, corticosteroids and ketamin. The role of radiotherapy bisphosphonates and invasive analgesic techniques in cancer pain will also be considered. Therefore, the new guidelines will be on: Pain management of cancer patients.
The work is undertaken by the EAPC Research Network, with Augusto Caraceni, Marie Fallon and Stein Kaasa as leading authors. They are collaborating with 26 international experts, each of them coordinating literature reviews to cover all topics.
It is well recognized that guidelines are not often fully implemented into clinical practice. Therefore, in this new version we will also include a recommendation of implementation of the pain guidelines into clinical practice, and thereby increase the potential for improved pain control in patients with cancer.
In order to have a basic discussion about recommendations, we would like to receive input from all our health care colleagues.
We would like to get your advice and feedback. Please send us an e-mail if you would like to contribute to this work.
We are looking forward to receiving your input and collaboration in order to make the best guidelines for cancer pain.
During the recent EAPC congress in Copenhagen, the outlines of the guidelines were presented. If you are interested in details, the power point presentations from this session are available for download here:
– by Elene Janberidze
Depression and depressive symptoms in general are burdensome, especially for patients with advanced stage cancer. Many of those patients have poorer prognosis and poorer quality of life. The prevalence of depression and depressive symptoms in those patients vary from 2% to 56% which could be due to that we as health care providers are not good enough to identify depression and depressive symptoms. We may think this is a normal part of having cancer and also part of the dying process. However, some patients experiencing depressive symptoms and/or depression can be treated and thus both the patients and their families may have better quality of life. Therefore it is important to study these patients.
The main reason for choosing patients with end-stage cancer in their last 24 hours of life was that patients in this very last period of life are not so well investigated. This might be due to the fact that many are too ill to be included in studies. As there were data available in this large population based study form the Netherlands, it was an opportunity to learn more about cancer patients at the very end of life. Usually we recommend to ask the patients to report about their subjective symptoms, however at this stage, such information in most cases has to be collected by asking relatives or by letting health care providers report about the symptoms as it was in this study.
Our findings showed that according to attending and treating physicians more than one third of the patients were experiencing depressive symptoms in the last 24 hours of life. It seems like that patients older than 80 years had less severe depressive symptoms than the younger. Physicians working in nursing homes in the Netherlands reported patients to have more severe symptoms of depression than general practitioners and physicians in other specialties. In patients with more severe symptoms of depression also pain specialists or palliative care consultants and psychiatrists or psychologists were involved in the care. Patients having depressive symptoms were also having other symptoms such as fatigue, confusion, and anxiety.
Diagnosing depression is challenging, especially in patients with somatic illnesses such as cancer. Symptoms such as fatigue can be related to the cancer, its treatment or interpreted as a sign of depression. Depressive symptoms could be viewed as a normal part of the dying process or could also indicate presence of depression. To be able to screen for and to recognize depressive symptoms is an important task for health care providers requiring evidence based knowledge and skills in order to offer appropriate care. If depressive symptoms are recognised early, patients can be offered adequate treatment. Doctors should investigate the patient further and recommend psychological interventions as needed. However, at the very end of life (last hours and days), it is normal that patients are withdrawing as part of the dying process.
The article which describes the study was recently published online in BMJ Supportive & Palliative Care: Janberidze E, Pereira SM, Hjermstad MJ, Knudsen AK, Kaasa S, van der Heide A, Onwuteaka-Philipsen B; Depressive symptoms in the last days of life of patients with cancer: a nationwide retrospective mortality study, on behalf of Euro Impact; 2015.
My name is Kristin and I am a medical student in Canada who is in Trondheim, Norway, for a research exchange with the PRC. The exchange program is organized by the International Federation of Medical Students’ Association (IFMSA) and it facilitates medical students from around the world participating in research or clinical observerships in other countries. The aim of the program is to increase international collaboration and to expose medical students to various medical systems and different clinical experiences. Through this program I was assigned to work with the PRC at St. Olav’s Hospital in Trondheim.
Visiting the Cancer Clinic together with Erik Løhre, head of the Palliative Unit.
The exchange is one month long so I have been spending the month of August here, working on research related to pain classification and assessment in cancer patients. My role has been to help one of the post-doctorate fellows (Yulan Lin) with a systematic literature review that aims to summarize the pain classification and assessment systems and methods that are currently being used in cancer pain research around the world. When I first arrived I helped conduct database searches of MEDLINE, EMBASE, Cochrane Central Register, PsychINFO, CINAHL and AMED to identify relevant articles in the literature. Since the initial search I have been screening the abstracts to flag papers that are relevant to our review. The next step is to review the full articles and extract information about the types of assessment and classification tools that are used to characterize cancer pain.
It has been interesting for me to learn about writing a systematic review and to also compare how research is conducted here in Norway to how it is done in Canada (seems very similar to me!). I also had the opportunity to tour the pain management and cancer care clinics here at St. Olav’s which was a great chance for me to observe similarities and differences from our hospitals in Canada, especially because the pain clinic here is very well established and well regarded in the palliative care field. Also, chatting with medical students here has really been interesting, and contrasting the medical education system in Norway to the one I am enrolled in has given me some ideas of how to improve our system in Canada! Overall it has been a fantastic experience and the researchers and staff at the PRC have been wonderful – making me feel welcome and giving me the chance to explore the Norwegian health care system.
Thank you everyone!
– by Katrin Rut Sigurdardottir
This is a fundamental question when reading a scientific paper. Unfortunately, all too often the description of the patient population is insufficient in trials in end-of-life and palliative care. Many of us have read interesting papers from studies with impressive results, but due to the lack of an adequate description of the sample, the results have been useless to us.
Patients entering our trials, as well as health care professionals putting much effort into data collections, deserve that study results can be generalized to groups and settings beyond those included in the trial. One of the main reasons for many palliative care patients to participate in clinical studies, is that the results can be of help to others.
The need to standardize reporting has been recognized for many years. The PRC in collaboration with the EAPC-RN and the project PRISMA started in 2010 a process to develop and reach consensus on a basic set of variables to describe a palliative care cancer population. In a five step Delphi exercise, 64 experts from 30 countries reached consensus on 31 variables to be included in the EAPC Basic Dataset. The paper describing the work was recently published online in Palliative Medicine:
Katrin R Sigurdardottir, Stein Kaasa, Jan H Rosland, Claudia Bausewein, Lukas Radbruch, Dagny F Haugen, on behalf of PRISMA: The European Association for Palliative Care basic dataset to describe a palliative care cancer population: Results from an international Delphi process.
The EAPC basic dataset of patient characteristics and medical variables provides a unique platform for standardizing research reporting, and a common framework for researchers, clinicians, and other palliative care stakeholders. The EAPC basic dataset is now available as PDF files on the PRC website, and will soon also be available on the EAPC homepage.
I strongly encourage researchers and clinicians to start using the dataset. We owe that to patients participating in our trials.
Ever struggled with writing your research article? Based on his 25 years of experience in writing articles PRC director Stein Kaasa gives you the recipe for writing a nice and tight article in about 35 minutes (only one presupposition: You know what you want to write about).
How do you get started?
- You start by writing the overall aim of the article/project in 1-2 sentences – crispy clear!
- When you have written it – understand it! If you do not get the story, you cannot tell anyone else about it.
- Keep in mind that the overall aim should lead to an overall conclusion.
- Then, write down your research questions. Research questions are sentences with a question mark at the end.
- Research questions should put the article into a context – these are the questions you will be answering in your discussion.
Move on to the Introduction
- Do you know the two main aims of the introduction? Here they are:
- Introduce the reader into the level of evidence in the field, based on existing literature. This should show the reader why your study makes sense in the field. Give the reader the most important references. You don’t have to include 70 references, 20 might be a sufficient number (especially since you need to refer to them once more; in the discussion).
- Present the overall aim and research questions (which you have already written…)
- The reader should get an appropriate impression of what your article is about by reading the first (main information on what the article is about) and last (aims and RQ’s) paragraph of the introduction.
- For the paragraphs in-between, write down in keywords your 3-5 main messages/themes. Then fill in the details and structure the text according to the overall rule: One idea – one message – one paragraph.
Materials and methods
- The easy one.
- Simply write down what you have done, how you have done it – and with whom.
- Also quite easy.
- First, make the tables. You might plan which tables to make long before the analysis have even started. All the results might be put into tables. Make as many as you like and save all of them in case you need them later, e.g. for a conference speech.
- Table 1: Most often patient characteristics
- Table 2: Presentation of main outcomes (might eventually be converted into a figure)
- Table 3-10: More outcomes
- Give the tables functional headings and make sure they are understandable independent of the text
- Secondly, consider if any of the findings could be presented in a figure – such as a graph or a bar chart
- Finally, write the results narratively. Paragraph by paragraph, guide the reader through the tables. No nitty-gritty details, no interpretations, and no emotions. Ice cold!
And then, the discussion
- Unfortunately or fortunately, the writing recipe is not sharply defined for the discussion. However, we offer some strategic approaches:
- Decide upon the 4-5 main points for discussion and write them down as keywords. Fill in according to the rule presented above.
- The first paragraph might be a summary of the main findings; a teaser.
- Discuss the main findings. This means: Answer your research questions. For your sake, I hope you have formulated them precisely.
- You probably had at least two research questions. You get the drill by now – discuss one of them at a time, one paragraph for each.
- Remember to go back to the introduction in order to relate your findings to the literature you presented there (you got an obvious hint about this above). Reflect on this for a minute.
- Present the study’s limitations, i.e. weaknesses related to material and methods.
- We are getting close to the final now, and here are two parts of the discussion that might demand some extra effort:
- Put the results into a larger context. This means to reflect upon your overall aim (which you, thank goodness, have written crispy clear upfront)
- Show how the reader could apply your findings in the clinic or in further research.
- The conclusion – phew! (Actually, you might want to write this directly after writing your aim – and what a relief – then you have finished your article before this last bullet point.). If the conclusion does not correspond with the introduction – start over.
Writing informed consent forms for patients who are asked to take part in clinical trials could be really challenging. The writer (the investigator) on the one hand has to fulfill the content requirements of such forms from ethical guidelines and ethics review board, and on the other hand he has to present the content in a way that all the eligible participants in his study can understand. Here are a few suggestions for what to bear in mind when explaining the trial to your patients:
1. Let research be the main topic, not treatment. Of course, treatment procedures are necessary to explain to the reader, but the treatment should be clearly presented as part of a trial.
2. Clarify the consent form is not merely information about a study, but that the information is conveyed because the reader is supposed to use it as a decision support in the consent process. This could be stated for instance by use of metainformation such as “You are asked to take part in a medical study. The information you get in this form and from your physician is supposed to help you decide whether or not you want to take part in the study”.
3. Clarify the relationship between the reader and the writer. It is a possible source of confusion that the actors in the consent process (and the whole trial situation) have dual roles: The doctor is also an investigator, and the patient is also a trial participant. Being a trial participant have other implications than being “only” a patient.
4. Orient the information to the target reader, i.e. the possible trial participant (not a regular patient, not the ethics review board). Explain the implications of consenting and of refusing.
5. Explain expert terms; do not avoid them. Consent form most often have to consist of information about complex medical research. Expert terms might be necessary in order to make the information sufficiently precise. Use them, and explain them in lay terms.
In September 2011, the United Nations hosted its second only Heads of State summit on health. The topic was non-communicable diseases. The four major disease streams were cardiovascular disease, respiratory disease, cancer and diabetes.
Each of these diseases has a group of people who will experience progressive disease with an increasing symptom burden. This burden will be seen in resource poor countries in increasing numbers in the decades ahead.
The Union for International Cancer Control (UICC) was active in advocating for good palliative care as part of the key planning that needs to be done. There was a small committee with representatives from around the globe who put together key fact sheets. Sadly the final communiqué of the summit only mentioned palliative once, but the resources developed are now being made widely available. They can be downloaded here and here, and focus on the practical things that can be done at a policy level to improve palliative care at a jurisdictional level.
Posted by David Currow, Professor, Flinders University, Australia.